Induced endogenous autotoxicity in

1. Abstract 2. Introduction 3. Materials and methods 3.1. Decapitation pruning 3.2. Exogenous application of CPT 3.3. External application of auxin 3.4. Isolation of compounds 3.5. Cytotoxicity assays 3.6. DNA TOP1 assays 3.7. Statistical analysis 4. Results 4.1. Abnormal morphogenesis and elevated CPT levels following decapitation 4.2. Abnormal morphogenesis following exogenous application of CPT 4.3. Cytotoxicity and DNA TOP1 activity of isolated compounds 5. Discussion 5.1. Endogenous autotoxicity induced by elevated CPT levels 5.2. Auxin reduction as a triggering factor for induced in vivo biosynthesis of CPTs 5.2.1. Pruning reducing endogenous auxin levels increased CPT contents in plants 5.2.2. Exogenous application of auxin restored auxin-deficient dwarf mutations 5.2.3. Exogenous application of auxin decreased CPT levels in normal plants 5.2.4. Autotoxicity induced by auxin deficiency rather than auxin homeostasis 5.3. Defense may play limited roles in induced biosynthesis of CPTs 5.4. Detoxification and autotoxicity mechanisms in Camptotheca 6. Acknowledgements 7. References